Publications

Black, M., Cornell, J.F., Rabin, L., and Shachter, N.  Late presentation of acetaminophen hepatotoxicity. (1982)  Digestive Diseases and Sciences 27: 370-374.

Kopyt, N., Myers, A.R., Mandel, S., and Shachter, N.  Recurrent rhabdomyolysis as a manifestation of alcoholic myopathy. (1984)  Archives of Internal Medicine 144: 821-823.

Shachter, N., Perloff, J.K., Mulder, D.G.  Aortic dissection in Noonan's Syndrome (46XY Turner). (1984)  American Journal of Cardiology 54: 464-465.

Ishimura-Oka, K., Semenkovich, C.F., Faustinella, F., Goldberg, I.J., Shachter, N.S., Smith, L.C., Coleman, T., Hide, W.A., Brown, W.V., Oka, K. and Chan, L.  A missense (Asp250-Asn) mutation in the lipoprotein lipase gene in two unrelated families with familial lipoprotein lipase deficiency. (1992) Journal of Lipid Research 33: 745-754.

Shachter, N.S., Zhu, Y., Walsh, A., Breslow, J.L., Smith, J.D.  Localization of a liver-specific enhancer in the apolipoprotein E/CI/CII gene locus. (1993) Journal of Lipid Research 34: 1699-1707.

Haubenwallner, S., Hörl, G., Shachter, N.S., Presta, E., Fried, S.K., Kostner, G.M., Breslow, J.L., Zechner, R.  A novel missense mutation in the gene for lipoprotein lipase resulting in a highly conservative amino acid substitution (Asp180-Glu) causes familial chylomicronemia (type I hyperlipoproteinemia). (1993) Genomics 18: 392-396.

Shachter, N.S., Hayek, T., Leff, T., Smith, J.D., Rosenberg, D.W., Walsh, A., Ramakrishnan, R., Goldberg, I.J., Ginsberg, H.N., Breslow, J.L.  Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. (1994) Journal of Clinical Investigation 93: 1683-1690.

Shachter, N.S., Weinberger, J. Mutations of the LDL receptor gene and familial hypercholesterolemia. (1994) Trends in Endocrinology and Metabolism 5: 245-249.

Shachter, N.S., Ebara, T., Ramakrishnan, R., Steiner, G., Breslow, J.L., Ginsberg, H.N., Smith, J.D. Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein CI. (1996) Journal of Clinical Investigation 98: 846-855.

Ebara, T., Ramakrishnan, R., Steiner, G., Shachter, N.S. Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E-null mice: Apolipoprotein CIII-induced hypertriglyceridemia is not mediated by effects on apoE. (1997) Journal of Clinical Investigation 99: 2672-2681.

Harris, W.S., Ginsberg, H.N., Aranakul, N., Shachter, N.S., Windsor, S.L., Adams, M., Berglund, L., Osmundsen, K. Safety and efficacy of Omacor in severe hypertriglyceridemia. (1997) Journal of Cardiovascular Risk 4: 385-391.

Xu, Y., Berglund, L., Ramakrishnan, R., Mayeux, R., Ngai, C., Holleran, S., Tycko, B., Leff, T., and Shachter, N.S. A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E. (1999) Journal of Lipid Research 40: 50-58.

Ebara, T., Conde, K., Kako, Y., Liu, Y., Xu, Y., Ramakrishnan, R. Goldberg, I.J., and Shachter, N.S. Delayed catabolism of apoB48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice. (2000) Journal of Clinical Investigation 105: 1807-1818.

Shachter, N.S. Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. (2001) Current Opinion in Lipidology 12: 297 - 304

Petit-Turcotte, C., Stohl, S.M., Beffert, U., Cohn, J.S., Aumont, N., Tremblay, M., Dea, D., Yang, L., Poirier, J., and Shachter, N. S. Apolipoprotein C-I Expression in the Brain in Alzheimer’s Disease. (2001) Neurobiology of Disease 8: 953 - 963 .

Vega-Lopez, S., Conde, K., Vidal-Quintanar, R.L., Shachter, N.S. and Fernandez, M.L. Sex and Hormonal Status Influence the Effects of Psyllium on Lipoprotein Remodeling and Composition. (2002) Metabolism 51: 500-507.

Herron, K.J., Vega-Lopez, S., Conde, K., Ramjiganesh, T., Roy, S., Shachter, N.S., and Fernandez, M.L. Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge. (2002) Journal of the American College of Nutrition 21: 250-258.

Conde-Knape, K., Bensadoun, A., Sobel, J. H., Cohn, J. S., and Shachter, N. S. Overexpression of Apolipoprotein C-I in Apolipoprotein E-null Mice: Severe Hypertriglyceridemia due to Inhibition of Hepatic Lipase. (2002) Journal of Lipid Research 43: 2136 - 2145 .

Herron, K.L., Vega-Lopez, S., Conde, K., Ramjiganesh, T., Shachter, N.S., and Fernandez, M.L. Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism. (2003) Journal of Nutrition 133: 1036-1042.

Lofgren, I., Herron, K., Zern, T., West, K., Patalay, M., Shachter, N.S., Koo, S.I., Fernandez, M.L. Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women. (2004) Journal of Nutrition 134: 1071-1076.

Tycko, B., Lee, J. H., Ciappa, A., Saxena, A., Li, C.-M., Feng, L., Yang, L., Arriaga, A., Stern, Y., Lantigua, R., Shachter, N., and Mayeux, R. APOE and APOC1 Promoter Polymorphisms and the Risk of Alzheimer Disease in African American and Caribbean Hispanic Individuals. (2004) Archives of Neurology 61: 1434-1439.

Conde-Knape, K., Okada, K., Ramakrishnan, R., and Shachter, N.S. Overexpression of apoC-III produces lesser hypertriglyceridemia in apoB48-only gene-targeted mice than in apoB100-only mice. (2004) Journal of Lipid Research 45: 2235-2244.

Liu, Y., Yang, L., Conde-Knape, K., Beher, D., Shearman, M.S., and‎ Shachter, N.S. ‎Fatty acids increase presenilin 1 levels and gamma-secretase ‎activity in PSwt-1 cells‎ . (2004) Journal of Lipid Research 45: 2368-2376.

Ballesteros, M.N., Cabrera, R.M., del Socorro Saucedo, M., Aggarwal, D., Shachter, N.S., and Fernandez, M.L. High intake of saturated fat and early occurrence of specific biomarkers may explain prevalence of chronic disease in Northern Mexico. (2005) Journal of Nutrition 135: 70-73.

Shachter, N. S. ABCG1: How Critical for Cholesterol Transport? (2005) Cell Metabolism 1: 87-88.

Shachter, N. S., Rabinowitz, D., Stohl, S., Conde-Knape, K., Cohn, J. S., Deckelbaum, R. J., Berglund, L., and Shea, S. The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children. (2005) Atherosclerosis 179: 387-393.

Zern, T. L, Wood, R. J., Greene. C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape Polyphenols Exert a Cardioprotective Effect in Pre- and Postmenopausal Women by Lowering Plasma Lipids and Reducing Oxidative Stress. (2005) Journal of Nutrition 135: 1911-1917.

Lofgren, I., Zern, T., Herron, K., West, K., Sharman, M. J., Volek, J. S., Shachter, N. S., Koo, S. I., and Fernandez, M. L. Weight loss associated with reduced intake of carbohydrate reduces the atherogenicity of LDL in premenopausal women. (2005) Metabolism Clinical and Experimental 54: 1133– 1141. 

Wood, R. J, Volek, J. S., Liu, Y., Shachter, N. S., Contois, J. H., and Fernandez, M. L. Carbohydrate Restriction Alters Lipoprotein Metabolism by Modifying VLDL, LDL, and HDL Subfraction Distribution and Size in Overweight Men. (2006) Journal of Nutrition 136: 384-389.

Qu, S, Perdomo, G., Su, D., D'Souza, F. M., Shachter, N. S., Dong, H. H. Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice. (2007) Journal of Lipid Research 48: 1476-1487.

Book Chapters

Rodino, M. A., Shachter, N., and Shane, E: 1999. Endocrine and metabolic complications of organ transplantation.  In Transplantation. Ginns LC, Cosimi AB, Morris PJ, editors. Blackwell Science, Boston 672-684.


Shachter, N. S., Zimetbaum, P., and Frishman, W. H. 2003. Lipid-Lowering Drugs. In Cardiovascular Pharmacotherapeutics. Frishman, W. H., Sonnenblick, E. H., and Sica, D. A., editors. McGraw-Hill, New York, NY, 317-353.

Abstracts

Shachter, N.S., Hayek, T., Leff, T., Smith, J.D., Rosenberg, D.W., Walsh, A., Ramakrishnan, R., Ginsberg, H.N., Breslow, J.L.  Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. (1993) Circulation 88: I-270


Shachter, N.S., Ebara, T., Ramakrishnan, R., Smith, J.D. Overexpression of apolipoprotein (apo) CI causes hypertriglyceridemia and decreased remnant clearance in transgenic (tg) mice. (1995) Circulation 92: I-106


Xu, Y., Leff, T., Shachter, N.S.  A common polymorphism in the apoCI promoter significantly increases apoCI gene expression. (1996) Circulation 94: I-274
Ebara, T., Shachter, N.S.  Chylomicronemia due to overexpression of apoCIII in apoE gene-knockout mice. (1996) Circulation 94: I-699


Shachter, N.S., Harris, W.S., Osmundsen, K., Ginsberg, H.N.  Omacor and severe hypertriglyceridemia. (1997) 4th International Symposium on Multiple Risk Factors in Cardiovascular Disease.  Washington, D.C. April 23-25, 1997


Ebara, T., Shachter, N. S.  Diabetes causes hypertriglyceridemia and hypercholesterolemia in apoB48-only but not in apoB100-only gene-targeted mice. (1997) Circulation 96: I-107


Xu, Y., Shachter, N. S. ApoCI HpaI polymorphism: Racial Difference in linkage dysequilibrium with ApoE alleles and functional effect on plasma lipoprotein levels. (1998) Circulation 97:


Ebara, T., Xu, Y., Kraemer, F., Reue, K., Ginsberg, H. N., Shachter, N. S. Hyperglycemia and hypertriglyceridemia in hormone-sensitive lipase-overexpressing transgenic mice. (1998) Diabetes 47 (Suppl 1): A31


Xu, Y., Ramakrishnan, R., Holleran, S., Ginsberg, H. N., Shachter, N. S. The –491 A/T genetic polymorphism of apolipoprotein E has a large and significant effect on fasting and postprandial triglyceride levels. (1998) Circulation 98: I-790


Conde, K., Kako, Y., Ebara, T., Xu, Y., Ramakrishnan, R., Goldberg, I. J., Shachter, N. S. Hyperlipidemia in Streptozotocin Diabetic Mice is Associated with Selective Impairment of ApoB48-Particle Clearance, Related to Increased C Apolipoproteins and Decreased Liver Heparan Sulfate (1999) Circulation 100: I-329


Shachter, N. S., Ramakrishnan, R., Stohl, S., Holleran, S., Bray, M. S., Park, E., Chambless, L. E., Sharrett, A. R.,Boerwinkle E. The Hpa I RFLP of apoC-I predicts plasma triglyceride levels in African-Americans: The ARIC Study. (1999) Circulation 100: I-821


Conde, K., Okada, K., Shachter, N. S. Overexpression of apoC-III produces lesser postprandial hypertriglyceridemia in apoB48-only gene-targeted mice than in apoB100-only mice. (2001) Arteriosclerosis, Thrombosis and Vascular Biology 21: 662


Conde, K., Bensadoun, A., Shachter, N. S. Severe hypertriglyceridemia and remnant accumulation due to modest overexpression of human apolipoprotein (apo) C-I in apoE-null mice: ApoC‑I–induced hyperlipidemia appears not to be mediated via effects on apoE-mediated clearance. (2001) Arteriosclerosis, Thrombosis and Vascular Biology 21: 666


Shachter, N.S., Yang, L., Liu, Y., Forte, T.M., Chisholm, J.W., Parks, J.S.  Cultured Human Astrocytes Secrete Large Cholesteryl Ester- and Triglyceride-rich Lipoproteins Along with Endothelial Lipase.  Oral Presentation O1-03-02, The 9th International Conference on Alzheimer’s Disease and Related Disorders, Philadelphia, PA, July 17-22, 2004.


Shachter, N.S., Liu, Y., Yang, L., Conde-Knape, K., Beher, D., Shearman, M.  Fatty Acids Increase Presenilin 1 Levels and Gamma-Secretase Activity in PSwt-1 Cells.  Poster P4-296, The 9th International Conference on Alzheimer’s Disease and Related Disorders, Philadelphia, PA, July 17-22, 2004.

 

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